Vitamin D3 metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin D3 metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYP27A1, SYNPO_S685, and ITGAX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin D3 metabolic process activity versus CYP27A1 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYP27A1 →	+0.381	+0.053	.001	.005	2	6
PDAC	SYNPO_S685 →	-0.589	-0.044	.004	.006	3	4
GBM	ITGAX →	+0.411	+0.063	.002	.002	3	4
LUAD	LILRB4 →	+0.472	+0.128	<.001	<.001	3	4
CCRCC	HDGFL3 →	-0.438	-0.084	.003	.002	3	4
LUAD	SEPTIN4 →	-0.452	-0.116	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070640 vs CYP27A1 — OV

Explore this scatter interactively →