Vitamin D3 metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin D3 metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A3, PARP4, and IGFBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC44A3 grouped by Vitamin D3 metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC44A3 →	-2.443	-0.981	<.001	.004	3	5
LUNG_SCLC	PARP4 →	+0.933	+0.721	.001	.003	3	4
STOMACH	IGFBP3 →	+5.379	+1.039	<.001	.002	3	4
LUNG_SCLC	MDP1 →	-0.653	-0.839	.004	<.001	3	4
LARGE_INTESTINE	FAM72D →	+0.932	+1.071	.001	<.001	3	4
OESOPHAGUS	LYZ →	-0.620	-0.795	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC44A3 by Vitamin D3 metabolic process activity — LUNG_SCLC

Explore this box plot interactively →