Vitamin D3 metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin D3 metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2R1, LASP1, and UBE3C, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin D3 metabolic process activity versus CYP2R1 in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CYP2R1 →	+1.801	+1.308	.001	<.001	3	12
LUNG_NSCLC_LUAD	LASP1 →	-0.798	-0.888	<.001	<.001	3	8
BREAST	UBE3C →	-0.746	-0.974	.005	<.001	2	8
BLOOD_Myeloma	CHMP1A →	-0.602	-0.116	.008	.002	3	7
BLOOD_Myeloma	C16orf87 →	-0.918	-0.151	.002	.004	3	7
CNS	CYP27B1 →	+1.595	+1.014	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070640 vs CYP2R1 — STOMACH

Explore this scatter interactively →