Transepithelial transport

Across TCGA cell cohorts, RNA activity of the Transepithelial transport pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CXADR, SLC12A2, and PKP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transepithelial transport activity versus CXADR in BLOOD_Leukemia (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CXADR →	+2.898	+1.224	<.001	<.001	3	9
PANCREAS	SLC12A2 →	+2.082	+1.344	.004	.002	3	8
SKIN	PKP1 →	+4.043	+1.922	.001	<.001	3	7
BLOOD_Leukemia	MCU →	+0.906	+0.650	<.001	.002	3	6
OVARY	CD47 →	+2.550	+1.432	<.001	<.001	3	6
OVARY	RPL24 →	-1.017	-1.364	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070633 vs CXADR — BLOOD_Leukemia

Explore this scatter interactively →