Regulation of centromeric sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Regulation of centromeric sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO5, MCM7, and CSE1L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of centromeric sister chromatid cohesion activity versus XPO5 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XPO5 →	+0.548	+0.061	<.001	<.001	3	8
LUAD	MCM7 →	+0.508	+0.066	.003	<.001	3	8
UCEC	CSE1L →	+0.242	+0.066	.001	.004	2	8
BRCA	FEN1 →	+0.513	+0.058	<.001	<.001	3	7
GBM	THOC2 →	+0.183	+0.040	.002	.004	3	7
GBM	MCM4 →	+0.713	+0.091	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070602 vs XPO5 — BRCA

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