Centromeric sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Centromeric sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, SMC2, and TOP2A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centromeric sister chromatid cohesion activity versus RFC2 in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RFC2 →	+0.405	+0.082	<.001	<.001	3	9
GBM	SMC2 →	+0.725	+0.081	<.001	<.001	3	9
UCEC	TOP2A →	+1.201	+0.133	<.001	<.001	3	9
UCEC	TOP2A_S1106 →	+1.049	+0.090	.001	.002	3	9
LUAD	TOP2A_S1247 →	+1.050	+0.052	<.001	<.001	3	9
BRCA	TPX2 →	+0.767	+0.053	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070601 vs RFC2 — HNSC

Explore this scatter interactively →