Centromeric sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Centromeric sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGDIB, SGO1, and RNASE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centromeric sister chromatid cohesion activity versus ARHGDIB in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGDIB →	-0.513	-0.155	.002	.005	3	6
BRCA	SGO1 →	+0.620	+0.187	<.001	<.001	3	6
LUAD	RNASE1 →	-1.116	-0.166	<.001	<.001	3	5
LUAD	FUCA1 →	-0.426	-0.115	.001	.006	3	5
LSCC	KNSTRN →	+0.653	+0.196	<.001	<.001	3	5
BRCA	FOXM1 →	+1.103	+0.236	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070601 vs ARHGDIB — LSCC

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