Centromeric sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Centromeric sister chromatid cohesion pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASE1, DUSP7, and USP28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNASE1 grouped by Centromeric sister chromatid cohesion-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RNASE1 →	+0.275	+0.198	.001	<.001	3	4
KIDNEY	DUSP7 →	+0.197	+0.168	.001	<.001	3	4
KIDNEY	USP28 →	+0.260	+0.128	.003	<.001	3	4
LIVER	SAR1B →	+0.201	+0.109	.003	.001	3	4
CNS	RPIA →	-0.207	-0.084	.001	.003	3	4
SOFT_TISSUE	CD46 →	-0.384	-0.168	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNASE1 by Centromeric sister chromatid cohesion activity — KIDNEY

Explore this box plot interactively →