Dendrite self-avoidance

Across TCGA patient cohorts, RNA activity of the Dendrite self-avoidance pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, CYP1B1, and LUM, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite self-avoidance activity versus ACTA2 in UCEC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTA2 →	+1.705	+0.344	<.001	<.001	3	10
CCRCC	CYP1B1 →	+1.371	+0.836	<.001	<.001	3	10
CCRCC	LUM →	+2.078	+0.769	<.001	<.001	3	10
UCEC	TAGLN →	+1.399	+0.257	<.001	<.001	3	10
BRCA	NEXN →	+1.101	+0.475	<.001	<.001	3	10
OV	DDR2 →	+1.184	+0.900	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070593 vs ACTA2 — UCEC

Explore this scatter interactively →