Dendrite self-avoidance

Across TCGA cell cohorts, RNA activity of the Dendrite self-avoidance pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL7A, SYNC, and USP7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite self-avoidance activity versus BCL7A in BONE (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BCL7A →	-2.276	-0.599	<.001	<.001	3	6
BONE	SYNC →	+4.221	+0.517	<.001	.001	3	6
SOFT_TISSUE	USP7 →	-0.626	-0.236	.002	<.001	3	5
BONE	SLC2A10 →	+3.538	+0.430	<.001	.004	3	5
SOFT_TISSUE	PGAM5 →	-0.958	-0.268	<.001	<.001	3	5
BONE	LAMP2 →	+1.818	+0.383	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070593 vs BCL7A — BONE

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