Positive regulation of vitamin D receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of vitamin D receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH2, LMTK3, and CFAP20DC, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vitamin D receptor signaling pathway activity versus MYH2 in HNSC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYH2 →	-1.819	-0.536	.003	.005	3	2
OV	LMTK3 →	-0.595	-0.639	.003	.002	3	2
OV	CFAP20DC →	+0.627	+0.815	<.001	<.001	3	2
OV	KISS1 →	-0.467	-0.549	.008	.001	3	2
OV	CENPBD1P1 →	-0.489	-0.816	.003	<.001	3	2
OV	FOXD2-AS1 →	+0.532	+0.626	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070564 vs MYH2 — HNSC

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