Regulation of vitamin D receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of vitamin D receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, LMNB1, and TMPO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vitamin D receptor signaling pathway activity versus GINS1 in UCEC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS1 →	+0.918	+0.670	<.001	.007	3	4
GBM	LMNB1 →	+0.675	+0.534	<.001	<.001	3	4
BRCA	TMPO →	+0.722	+0.802	<.001	<.001	3	4
GBM	CIP2A →	+0.522	+0.602	<.001	<.001	3	4
BRCA	PARPBP →	+0.463	+0.666	.005	.004	3	4
BRCA	ATRX →	+0.368	+0.446	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070562 vs GINS1 — UCEC

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