Regulation of vitamin D receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of vitamin D receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RXRA, KANK2, and VDR, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vitamin D receptor signaling pathway activity versus RXRA in SKIN (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RXRA →	+1.375	+0.156	<.001	<.001	3	11
BLOOD_Leukemia	KANK2 →	+1.491	+0.146	<.001	<.001	3	10
STOMACH	VDR →	+2.071	+0.251	<.001	<.001	3	8
BONE	NIBAN2 →	+2.226	+0.169	<.001	<.001	3	8
BONE	KIF13B →	+1.210	+0.117	.005	.007	3	8
LUNG_NSCLC_LUSC	LRP1 →	+2.262	+0.177	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070562 vs RXRA — SKIN

Explore this scatter interactively →