Vitamin D receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Vitamin D receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC5, LMNB1, and TMPO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin D receptor signaling pathway activity versus RFC5 in GBM (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC5 →	+0.445	+0.708	.001	.002	3	4
GBM	LMNB1 →	+0.984	+0.979	<.001	<.001	3	4
BRCA	TMPO →	+0.724	+0.805	<.001	<.001	3	4
GBM	CIP2A →	+0.729	+0.749	<.001	<.001	3	4
GBM	PARPBP →	+0.530	+0.535	<.001	.008	3	4
BRCA	RBM12 →	+0.413	+0.805	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070561 vs RFC5 — GBM

Explore this scatter interactively →