Response to interleukin-1

Across TCGA patient cohorts, RNA activity of the Response to interleukin-1 pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECSCR, SELP, and AKAP12, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-1 activity versus ECSCR in OV (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ECSCR →	+0.668	+0.287	<.001	.001	3	9
HNSC	SELP →	+1.146	+0.192	<.001	<.001	3	8
CCRCC	AKAP12 →	+0.978	+0.232	<.001	<.001	3	8
LSCC	MEDAG →	+1.185	+0.219	<.001	<.001	3	7
BRCA	CNRIP1 →	+0.799	+0.280	<.001	<.001	3	7
GBM	GYPC →	+1.973	+0.320	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070555 vs ECSCR — OV

Explore this scatter interactively →