Response to interleukin-1

Across TCGA pan-cancer cohorts, RNA activity of the Response to interleukin-1 pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 136 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Response to interleukin-1 pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRC, SKCM, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.515	0.727	<.001	117	view →
SKCM	OS	Median	All	0.419	0.272	<.001	60	view →
HNSC	DFS	Quartile	IV	0.612	0.311	<.001	47	view →
LGG	OS	Median	All	0.361	0.512	<.001	38	view →
THYM	OS	Tertile	II,III,IV	0.828	1.000	.001	27	view →
THCA	DFS	Tertile	II,III,IV	0.842	0.970	.002	25	view →
ESCA	DFS	Median	III,IV	0.491	0.229	.002	21	view →
GBM	DFS	Quartile	All	0.152	0.297	<.001	18	view →
LIHC	DFS	Median	II,III,IV	0.405	0.250	.020	15	view →
KIRP	OS	Median	II,III,IV	0.328	0.913	.005	12	view →
LUSC	DFS	Quartile	II,III,IV	0.257	0.484	.011	10	view →
OV	DFS	Quartile	III,IV	0.467	0.579	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0070555–KIRC (DFS)

Open the KIRC breakdown →