Response to interleukin-1

Across TCGA cell cohorts, RNA activity of the Response to interleukin-1 pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC29A1, CHAC2, and YIPF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-1 activity versus SLC29A1 in OVARY (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC29A1 →	-1.115	-0.194	.003	.004	3	5
OVARY	CHAC2 →	-0.907	-0.256	<.001	<.001	3	5
BLOOD_Myeloma	YIPF4 →	+0.928	+0.161	.002	.005	3	5
LUNG_SCLC	CD47 →	+1.317	+0.123	.009	.002	3	5
LUNG_NSCLC_LUAD	ATP5F1C →	-0.665	-0.184	.006	.001	3	5
BLOOD_Lymphoma	PERM1 →	+0.963	+0.124	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070555 vs SLC29A1 — OVARY

Explore this scatter interactively →