Response to fatty acid

Across TCGA patient cohorts, RNA activity of the Response to fatty acid pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S222, ELN, and MAOA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fatty acid activity versus SNTB2_S222 in OV (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNTB2_S222 →	+1.044	+0.069	.007	.002	2	9
OV	ELN →	+0.798	+0.034	<.001	<.001	3	8
LSCC	MAOA →	+0.614	+0.068	<.001	.004	3	8
BRCA	GPX3 →	+0.597	+0.032	<.001	<.001	3	8
OV	SRRM2_S1694 →	-0.983	-0.036	<.001	<.001	3	7
BRCA	PBK →	-0.522	-0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070542 vs SNTB2_S222 — OV

Explore this scatter interactively →