Response to fatty acid

Across TCGA patient cohorts, RNA activity of the Response to fatty acid pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS1, LHFPL6, and RASSF8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fatty acid activity versus IRS1 in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+1.117	+0.350	<.001	<.001	3	6
LSCC	LHFPL6 →	+0.421	+0.149	.003	.002	3	6
UCEC	RASSF8 →	+1.041	+0.270	<.001	<.001	3	5
UCEC	FBXO32 →	+0.647	+0.180	.003	.003	3	5
OV	ZCCHC24 →	+0.777	+0.261	<.001	<.001	3	5
COAD	FABP4 →	+2.514	+0.599	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070542 vs IRS1 — UCEC

Explore this scatter interactively →