Response to fatty acid

Across TCGA cell cohorts, RNA activity of the Response to fatty acid pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAN3, PLA2R1, and STIM2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAN3 grouped by Response to fatty acid-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PAN3 →	+0.526	+0.589	<.001	.004	3	3
CNS	PLA2R1 →	+0.825	+0.646	.001	.002	3	3
OESOPHAGUS	STIM2 →	-0.853	-0.624	<.001	.006	3	3
OESOPHAGUS	FBXO41 →	+1.902	+0.810	<.001	.009	3	3
OVARY	COL17A1 →	+1.302	+0.603	.008	.008	3	3
OVARY	FAT2 →	-1.214	-0.630	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAN3 by Response to fatty acid activity — SKIN

Explore this box plot interactively →