Protein K63-linked deubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K63-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A3, LINC01712, and CYP20A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K63-linked deubiquitination activity versus SLC15A3 in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC15A3 →	+0.470	+0.572	.005	.006	3	3
OV	LINC01712 →	+0.035	+1.037	.004	<.001	3	3
LUAD	CYP20A1 →	-0.289	-0.304	.002	.003	3	3
COAD	H2AC4 →	+0.324	+0.533	.002	<.001	3	3
HNSC	LMCD1 →	-0.547	-0.166	.005	.008	3	3
GBM	TRIM21 →	+0.373	+0.548	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070536 vs SLC15A3 — GBM

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