Protein K63-linked deubiquitination

Across TCGA pan-cancer cohorts, RNA activity of the Protein K63-linked deubiquitination pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 31 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Protein K63-linked deubiquitination pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRP, KICH, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.745	0.913	.001	43	view →
KICH	OS	Quartile	II,III,IV	0.441	1.000	.001	43	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	36	view →
ACC	DFS	Median	All	0.404	0.756	<.001	27	view →
MESO	OS	Tertile	IV	0.063	0.717	.006	24	view →
BLCA	DFS	Tertile	II,III,IV	0.506	0.627	.012	21	view →
SCLC	DFS	Median	III,IV	0.520	0.210	.013	21	view →
SKCM	OS	Median	II,III,IV	0.927	0.761	.003	20	view →
LUSC	DFS	Median	All	0.707	0.611	.018	20	view →
READ	OS	Quartile	All	0.728	0.327	.003	18	view →
UCS	DFS	Quartile	II,III,IV	0.791	0.191	.021	12	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0070536–KIRP (DFS)

Open the KIRP breakdown →