Protein K63-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K63-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTN2A2, LRRK1, and C6orf62, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTN2A2 grouped by Protein K63-linked deubiquitination-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BTN2A2 →	-0.947	-0.510	.005	.009	3	5
URINARY_TRACT	LRRK1 →	-1.509	-0.424	.005	.006	3	4
OESOPHAGUS	C6orf62 →	-0.559	-0.258	.001	.004	2	5
OESOPHAGUS	SH2D5 →	-1.916	-0.348	.001	.001	3	4
LUNG_NSCLC_LUSC	SPDL1 →	-1.221	-0.282	.008	.002	2	5
BLOOD_Myeloma	SETD6 →	+1.068	+0.284	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTN2A2 by Protein K63-linked deubiquitination activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →