Calcium ion import

Across TCGA patient cohorts, RNA activity of the Calcium ion import pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR36, NCAPD2, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion import activity versus WDR36 in GBM (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR36 →	-0.238	-0.056	<.001	<.001	3	8
UCEC	NCAPD2 →	-0.584	-0.051	<.001	<.001	3	8
UCEC	RSU1 →	+0.392	+0.034	<.001	<.001	3	7
LSCC	SMC2 →	-0.485	-0.036	<.001	<.001	3	7
HNSC	SNX9 →	+0.342	+0.055	<.001	<.001	3	7
GBM	NOC2L →	-0.220	-0.050	.006	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070509 vs WDR36 — GBM

Explore this scatter interactively →