Calcium ion import

Across TCGA patient cohorts, RNA activity of the Calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL21P134, RNU1-75P, and PTTG3P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion import activity versus RPL21P134 in HNSC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL21P134 →	+0.352	+0.157	.002	.001	3	2
PDAC	RNU1-75P →	-0.339	-0.183	.003	.004	3	2
LUAD	PTTG3P →	-0.542	-0.387	<.001	.003	3	2
PDAC	CSE1L-AS1 →	-0.190	-0.185	.002	.009	3	2
PDAC	TRBV29-1 →	-0.423	-0.139	.006	.001	3	2
PDAC	HOXB7 →	+0.643	+0.164	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070509 vs RPL21P134 — HNSC

Explore this scatter interactively →