Calcium ion import

Across TCGA cell cohorts, RNA activity of the Calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPP5, PPP1R16A, and ALG14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPP5 grouped by Calcium ion import-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MPP5 →	-1.244	-1.325	<.001	<.001	3	5
LARGE_INTESTINE	PPP1R16A →	-0.695	-1.008	.009	<.001	3	3
LARGE_INTESTINE	ALG14 →	-0.879	-0.860	<.001	<.001	3	3
STOMACH	COA1 →	+0.743	+1.108	.003	.003	3	3
SKIN	PAICS →	+0.474	+0.745	.006	.002	3	3
BLOOD_Myeloma	ESS2 →	-1.038	-1.344	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPP5 by Calcium ion import activity — LUNG_SCLC

Explore this box plot interactively →