Calcium ion import

Across TCGA cell cohorts, RNA activity of the Calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TINAGL1, LAMP3, and S100A2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion import activity versus TINAGL1 in LUNG_NSCLC_LUSC (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TINAGL1 →	-3.584	-0.072	<.001	.009	3	7
OESOPHAGUS	LAMP3 →	-1.938	-0.100	.001	.001	3	7
LUNG_NSCLC_LUSC	S100A2 →	-4.112	-0.097	.007	.001	3	7
BONE	SPTB →	-1.566	-0.065	.002	.003	3	7
BLOOD_Leukemia	C17orf99 →	-0.718	-0.050	<.001	<.001	3	7
OESOPHAGUS	PCSK1N →	-2.184	-0.106	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070509 vs TINAGL1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →