Cholesterol import

Across TCGA patient cohorts, RNA activity of the Cholesterol import pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD36, FABP4, and GPD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol import activity versus CD36 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD36 →	+1.310	+0.084	<.001	<.001	3	8
OV	FABP4 →	+1.039	+0.055	<.001	<.001	3	7
OV	GPD1 →	+1.483	+0.095	<.001	<.001	3	6
CCRCC	SHANK3 →	+0.400	+0.104	<.001	<.001	3	5
CCRCC	ERG_S81 →	+0.742	+0.114	.001	<.001	3	5
CCRCC	SHANK3_S1570 →	+0.629	+0.094	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070508 vs CD36 — OV

Explore this scatter interactively →