Cholesterol import

Across TCGA patient cohorts, RNA activity of the Cholesterol import pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCT1, CD36, and RNF44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol import activity versus MYCT1 in CCRCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYCT1 →	+0.761	+0.151	<.001	<.001	3	5
BRCA	CD36 →	+1.454	+0.147	.001	<.001	3	5
HNSC	RNF44 →	-0.637	-0.137	.001	.002	3	5
CCRCC	DIPK2B →	+0.693	+0.154	.001	.001	3	5
CCRCC	CLEC1A →	+0.867	+0.196	<.001	<.001	3	5
CCRCC	SHE →	+0.686	+0.176	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070508 vs MYCT1 — CCRCC

Explore this scatter interactively →