Cholesterol import

Across TCGA cell cohorts, RNA activity of the Cholesterol import pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP17, TXNDC11, and FBN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP17 grouped by Cholesterol import-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ARHGAP17 →	+0.752	+1.266	.001	<.001	3	4
OVARY	TXNDC11 →	-0.627	-0.840	<.001	.004	3	3
LUNG_NSCLC_LUSC	FBN1 →	-2.189	-1.339	.008	<.001	3	3
LUNG_NSCLC_LUSC	IQCK →	-1.444	-1.089	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	IFIT1 →	-3.643	-1.597	<.001	<.001	3	3
LUNG_NSCLC_LUSC	MTARC1 →	+2.513	+1.298	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP17 by Cholesterol import activity — PANCREAS

Explore this box plot interactively →