Cholesterol import

Across TCGA cell cohorts, RNA activity of the Cholesterol import pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMBIM6, MYO6, and CLDN23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol import activity versus TMBIM6 in OESOPHAGUS (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMBIM6 →	+1.196	+1.838	.004	<.001	3	4
OESOPHAGUS	MYO6 →	+1.703	+1.742	.001	<.001	3	3
OVARY	CLDN23 →	+1.168	+1.579	<.001	<.001	3	3
SKIN	EID1 →	-1.364	-1.320	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	EGLN3 →	+1.478	+1.471	.009	<.001	3	3
OVARY	CLCF1 →	+1.912	+1.504	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070508 vs TMBIM6 — OESOPHAGUS

Explore this scatter interactively →