Thrombin-activated receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Thrombin-activated receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IQGAP2, VWA5A, and HPGD, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thrombin-activated receptor signaling pathway activity versus IQGAP2 in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IQGAP2 →	+0.484	+0.089	<.001	<.001	3	8
HNSC	VWA5A →	+0.501	+0.068	<.001	.003	3	7
LUAD	HPGD →	+1.160	+0.112	<.001	<.001	3	7
PDAC	IQGAP2_S1358 →	+0.548	+0.080	<.001	<.001	3	7
LUAD	ELP2 →	-0.141	-0.061	.002	.006	3	7
BRCA	HAAO →	+0.765	+0.063	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070493 vs IQGAP2 — PDAC

Explore this scatter interactively →