Leukocyte aggregation

Across TCGA patient cohorts, RNA activity of the Leukocyte aggregation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, CRLF3, and DEF6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte aggregation activity versus STK10 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STK10 →	+0.466	+0.073	.001	<.001	3	10
BRCA	CRLF3 →	+0.304	+0.039	<.001	<.001	3	10
GBM	DEF6 →	+0.620	+0.129	<.001	<.001	3	10
GBM	FYB1 →	+0.831	+0.143	<.001	<.001	3	10
GBM	AMPD3 →	+0.712	+0.140	<.001	<.001	3	10
GBM	SKAP2 →	+0.771	+0.139	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070486 vs STK10 — OV

Explore this scatter interactively →