Leukocyte aggregation

Across TCGA patient cohorts, RNA activity of the Leukocyte aggregation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTIP, PTPN22, and CD226, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte aggregation activity versus CYTIP in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYTIP →	+1.089	+0.221	<.001	.002	3	9
BRCA	PTPN22 →	+0.939	+0.261	<.001	<.001	3	9
HNSC	CD226 →	+0.640	+0.195	<.001	<.001	3	9
BRCA	TRGC2 →	+1.491	+0.249	<.001	<.001	3	9
BRCA	NFAM1 →	+0.828	+0.202	<.001	.001	3	9
BRCA	CSF2RB →	+1.513	+0.299	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070486 vs CYTIP — BRCA

Explore this scatter interactively →