Leukocyte aggregation

Across TCGA cell cohorts, RNA activity of the Leukocyte aggregation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSN, CD44, and ELL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte aggregation activity versus MSN in URINARY_TRACT (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MSN →	+4.795	+0.754	.002	<.001	3	8
SOFT_TISSUE	CD44 →	+4.887	+0.635	.003	.001	3	8
SOFT_TISSUE	ELL2 →	+3.757	+0.584	<.001	.004	3	7
LIVER	CGN →	-3.676	-0.820	.002	.002	3	6
LUNG_NSCLC_LUAD	IKBIP →	+1.293	+0.363	<.001	<.001	3	6
URINARY_TRACT	MRC2 →	+3.064	+0.564	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070486 vs MSN — URINARY_TRACT

Explore this scatter interactively →