Nucleotide-binding oligomerization domain containing 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Nucleotide-binding oligomerization domain containing 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM14B, GPR137B, and ABCA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM14B grouped by Nucleotide-binding oligomerization domain containing 2 signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM14B →	+0.613	+0.954	<.001	.001	3	4
CNS	GPR137B →	-1.196	-1.175	.003	<.001	3	4
BREAST	ABCA2 →	-1.006	-0.789	<.001	.001	3	4
BREAST	MAN1C1 →	-1.007	-1.061	.002	<.001	3	4
BREAST	F11R →	-1.587	-1.093	.001	<.001	3	4
BREAST	SFMBT2 →	-1.031	-0.934	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM14B by Nucleotide-binding oligomerization domain containing 2 signaling pathway activity — BREAST

Explore this box plot interactively →