"Positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PADI2, EPHB2, and TDO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway" activity versus PADI2 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PADI2 →	+0.904	+0.176	<.001	.002	3	4
OV	EPHB2 →	+0.854	+0.176	.001	.002	3	4
OV	TDO2 →	+1.268	+0.184	.004	.002	3	4
OV	ITGA5 →	+1.034	+0.195	<.001	<.001	3	4
OV	LCP2 →	+0.971	+0.229	<.001	<.001	3	4
OV	SIGLEC1 →	+1.087	+0.252	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070426 vs PADI2 — LSCC

Explore this scatter interactively →