Cellular response to cold

Across TCGA patient cohorts, RNA activity of the Cellular response to cold pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL3A1, ITGA1, and MYH9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to cold activity versus COL3A1 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL3A1 →	+0.708	+0.055	<.001	<.001	3	5
LSCC	ITGA1 →	+0.374	+0.065	<.001	.004	3	5
LSCC	MYH9 →	+0.350	+0.064	<.001	.004	3	5
GBM	S100P →	+1.607	+0.088	<.001	.001	3	5
LSCC	SIPA1 →	+0.297	+0.055	<.001	.009	3	5
LSCC	STRAP →	-0.194	-0.061	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070417 vs COL3A1 — BRCA

Explore this scatter interactively →