Response to lipoteichoic acid

Across TCGA patient cohorts, RNA activity of the Response to lipoteichoic acid pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARVG, RIN3, and SAMSN1_S23, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lipoteichoic acid activity versus PARVG in GBM (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PARVG →	+0.549	+0.095	<.001	<.001	3	9
COAD	RIN3 →	+0.481	+0.055	<.001	.002	3	9
OV	SAMSN1_S23 →	+0.782	+0.101	<.001	<.001	3	9
OV	SASH3 →	+0.476	+0.112	<.001	<.001	3	9
OV	SKAP2 →	+0.765	+0.085	<.001	<.001	3	9
LSCC	STK10 →	+0.355	+0.111	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070391 vs PARVG — GBM

Explore this scatter interactively →