Response to lipoteichoic acid

Across TCGA cell cohorts, RNA activity of the Response to lipoteichoic acid pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHFPL6, PTPN23, and POLR1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LHFPL6 grouped by Response to lipoteichoic acid-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LHFPL6 →	+3.111	+0.492	.004	.003	3	5
PANCREAS	PTPN23 →	-0.673	-1.041	.004	.002	3	5
OVARY	POLR1A →	-0.813	-1.082	.001	.002	3	4
URINARY_TRACT	KIF26A →	-1.973	-1.956	<.001	<.001	3	4
OVARY	ANKRD13B →	-1.249	-0.756	.001	.002	3	4
BREAST	C22orf23 →	+0.339	+0.857	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LHFPL6 by Response to lipoteichoic acid activity — STOMACH

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