Response to lipoteichoic acid

Across TCGA cell cohorts, RNA activity of the Response to lipoteichoic acid pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTLL1, FGF13, and FGFBP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lipoteichoic acid activity versus TTLL1 in BREAST (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TTLL1 →	+1.239	+1.818	<.001	<.001	3	2
BREAST	FGF13 →	+3.047	+1.518	<.001	.001	3	2
BREAST	FGFBP2 →	+0.886	+1.838	.008	<.001	3	2
BREAST	EIF4EBP2 →	+1.503	+1.818	.001	<.001	3	2
BREAST	TNFRSF14 →	+3.700	+1.891	.002	.001	3	2
BREAST	NAALADL2 →	+2.178	+1.818	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070391 vs TTLL1 — BREAST

Explore this scatter interactively →