Response to lipoteichoic acid

Across TCGA cell cohorts, RNA activity of the Response to lipoteichoic acid pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are YK-4-279, Docetaxel, and BDF00022089a, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YK-4-279 grouped by Response to lipoteichoic acid-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	YK-4-279 →	+1.550	+0.284	.005	.006	2	6
BREAST	Docetaxel →	+0.631	+1.818	.003	<.001	3	5
CNS	BDF00022089a →	+0.955	+2.010	.003	.001	2	5
CNS	GSK343 →	+1.060	+2.107	.032	.008	3	4
CNS	Oxaliplatin →	+0.576	+2.010	.043	.001	2	5
CNS	GDC0810 →	+0.929	+2.028	.034	.015	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YK-4-279 by Response to lipoteichoic acid activity — LUNG_SCLC

Explore this box plot interactively →