Negative regulation of ERK1 and ERK2 cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of ERK1 and ERK2 cascade pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAWR, IRAK2, and RAE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERK1 and ERK2 cascade activity versus PAWR in GBM (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PAWR →	-0.767	-0.556	.008	.007	3	4
LSCC	IRAK2 →	+0.551	+0.210	<.001	.003	3	4
LSCC	RAE1 →	-0.462	-0.155	.001	.004	3	4
LSCC	TTC23 →	-0.345	-0.188	<.001	<.001	3	4
LUAD	CEP85L →	+0.311	+0.143	<.001	.001	3	4
LSCC	KPNA1 →	-0.436	-0.187	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070373 vs PAWR — GBM

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