Negative regulation of fat cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of fat cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STBD1, SELENOI, and UBXN6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fat cell proliferation activity versus STBD1 in LSCC (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STBD1 →	-0.438	-0.328	<.001	.006	3	3
CCRCC	SELENOI →	+0.274	+0.229	.003	.002	3	3
COAD	UBXN6 →	-0.363	-0.295	<.001	<.001	3	3
LSCC	FBXO5 →	+0.714	+0.265	<.001	.002	2	3
LSCC	TTK →	+0.634	+0.266	.003	.006	3	2
LSCC	SMC4 →	+0.694	+0.316	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070345 vs STBD1 — LSCC

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