Regulation of fat cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of fat cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TULP4, PYURF, and LMBRD2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TULP4 grouped by Regulation of fat cell proliferation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TULP4 →	+1.259	+1.630	.003	.001	3	3
SOFT_TISSUE	PYURF →	-0.635	-1.136	.007	.006	3	3
SOFT_TISSUE	LMBRD2 →	+0.589	+0.776	.002	.009	3	3
SOFT_TISSUE	RPL17 →	-0.894	-1.030	.001	.007	3	3
STOMACH	CD37 →	-1.015	-0.489	.002	<.001	3	3
URINARY_TRACT	CDYL →	+0.603	+0.388	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TULP4 by Regulation of fat cell proliferation activity — BONE

Explore this box plot interactively →