Regulation of fat cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of fat cell proliferation pathway is significantly associated with the total protein of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GATA3, JNK_pT183_Y185, and P-Cadherin, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fat cell proliferation activity versus GATA3 in LARGE_INTESTINE (Pearson r = 0.98).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GATA3 →	+0.460	+0.620	.012	.048	2	1
LARGE_INTESTINE	JNK_pT183_Y185 →	-0.526	-0.529	.006	.044	2	1
LARGE_INTESTINE	P-Cadherin →	-0.298	-0.413	.011	.026	2	1
LARGE_INTESTINE	Chk2_pT68 →	-0.406	-0.529	.012	.044	2	1
LARGE_INTESTINE	c-Jun_pS73 →	-0.542	-0.413	.001	.026	2	1
LARGE_INTESTINE	p21 →	+0.556	+0.413	.010	.026	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070344 vs GATA3 — LARGE_INTESTINE

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