Thyroid hormone transport

Across TCGA patient cohorts, RNA activity of the Thyroid hormone transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMC1, IMP4, and NIFK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone transport activity versus PSMC1 in UCEC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC1 →	-0.793	-0.847	.006	.004	2	4
OV	IMP4 →	-0.437	-0.174	.002	.003	3	3
OV	NIFK →	-0.476	-0.162	.002	.004	3	3
GBM	HBA2 →	+1.112	+0.179	.001	.004	2	4
HNSC	RN7SKP221 →	-0.181	-0.219	.001	.004	3	3
BRCA	CLPSL2 →	-1.064	-0.209	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070327 vs PSMC1 — UCEC

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