Positive regulation of G0 to G1 transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of G0 to G1 transition pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIRC5, MSRA, and CDKN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of G0 to G1 transition activity versus BIRC5 in UCEC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BIRC5 →	+0.739	+0.650	.003	<.001	3	4
GBM	MSRA →	-0.535	-0.515	<.001	<.001	3	4
UCEC	CDKN3 →	+0.632	+0.684	<.001	<.001	3	3
UCEC	ECT2 →	+0.575	+0.656	<.001	<.001	3	3
UCEC	NUP43 →	+0.237	+0.757	.004	<.001	3	3
UCEC	NCAPH →	+0.634	+0.645	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070318 vs BIRC5 — UCEC

Explore this scatter interactively →