Positive regulation of G0 to G1 transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of G0 to G1 transition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MD, CDK7, and CCZ1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5MD grouped by Positive regulation of G0 to G1 transition-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ATP5MD →	-0.855	-0.257	.003	.002	3	4
BREAST	CDK7 →	-0.559	-0.072	<.001	.006	3	4
LUNG_NSCLC_LUSC	CCZ1B →	+1.314	+0.278	.003	<.001	3	3
BLOOD_Lymphoma	FERMT3 →	+5.240	+0.194	.003	.005	2	4
OESOPHAGUS	ZKSCAN7 →	+0.986	+0.178	.003	.001	2	4
BLOOD_Lymphoma	PRKACB →	+3.075	+0.191	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5MD by Positive regulation of G0 to G1 transition activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →