Negative regulation of G0 to G1 transition

Across TCGA patient cohorts, RNA activity of the Negative regulation of G0 to G1 transition pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM2, RFC2, and TOP2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of G0 to G1 transition activity versus MCM2 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MCM2 →	+0.477	+0.066	.001	<.001	3	5
LUAD	RFC2 →	+0.272	+0.086	<.001	<.001	3	4
LUAD	TOP2A →	+0.783	+0.086	.002	<.001	3	4
GBM	UACA →	-0.280	-0.095	<.001	<.001	3	4
LUAD	ZWILCH →	+0.354	+0.065	.001	<.001	3	4
BRCA	CARMIL1_S122 →	+0.477	+0.042	.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070317 vs MCM2 — BRCA

Explore this scatter interactively →